(eurekalert.org) – Traumatic brain injury (TBI) is a major cause of mortality and morbidity, often causing lifelong disability for those who survive. Treatment is limited to supportive care, but stem cell therapy has received recent attention as a way to promote recovery for injuries to the central nervous system (CNS).
In this study, researchers transplanted human neural stem cells (hNSCs) into the brains of mice modeled with TBI to investigate whether the hosts' immune systems and the stem cells acting in concert would enhance repair. The researchers found that the transplanted hNSCs had a beneficial effect when the cells differentiated into a neuroprotective form (M2) of microglia (the main immune cells of the CNS) and subsequently reduced inflammatory responses generated by the injury. CONTINUE